Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 2/20 | 1.00 |
| ▸ | PPARA | Q07869 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | PPARG | P37231 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | PTGIR | P43119 | 7/20 | 0.64 |
| ▸ | PTGER2 | P43116 | 4/20 | 0.64 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.64 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.64 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.64 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.57 |
| ▸ | PTGFR | P43088 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SLCO2A1 | Q92959 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbacyclin SCHEMBL30905566 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL13539945 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL11090152 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL9643974 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL10732794 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL10439712 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL24340889 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL6082848 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL1479163 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG | |
| Carbacyclin SCHEMBL28444482 | 1.00 | PPARD (1.00) | PPARDPPARAMEN1KMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348275-A1 | PROSTACYCLIN COMPOSITIONS FOR REGULATION OF FRACTURE REPAIR AND BONE FORMATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2017-12-07 | — | — | US | claimed |
| US-9763911-B2 | Prostacyclin compositions for regulation of fracture repair and bone formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-09-19 | — | — | US | claimed |
| US-20150164853-A1 | PROSTACYCLIN COMPOSITIONS FOR REGULATION OF FRACTURE REPAIR AND BONE FORMATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2015-06-18 | — | — | US | claimed |
| US-20210059997-A1 | PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR CATARACT, MEDICINAL COMPOSITION FOR PREVENTING AND/OR TREATING CATARACT, USE OF PPAR ACTIVATOR FOR PRODUCING SAME, AND EYEDROPS | UNIVERSITY OF FUKUI (JP) | 2021-03-04 | — | — | US | disclosed |
| EP-3733203-A1 | PROPHYLACTIC AGENT AND/OR THERAPEUTIC AGENT FOR CATARACT, MEDICINAL COMPOSITION FOR PREVENTING AND/OR TREATING CATARACT, USE OF PPAR ACTIVATOR FOR PRODUCING SAME, AND EYEDROPS | University of Fukui (JP) | 2020-11-04 | — | — | EP | disclosed |
| US-20170348275-A1 | PROSTACYCLIN COMPOSITIONS FOR REGULATION OF FRACTURE REPAIR AND BONE FORMATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2017-12-07 | — | — | US | disclosed |
| US-9763911-B2 | Prostacyclin compositions for regulation of fracture repair and bone formation | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2017-09-19 | — | — | US | disclosed |
| US-20150164853-A1 | PROSTACYCLIN COMPOSITIONS FOR REGULATION OF FRACTURE REPAIR AND BONE FORMATION | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2015-06-18 | — | — | US | disclosed |
| EP-1201235-B1 | NEUROPATHY IMPROVERS CONTAINING NITROGENOUS COMPOUNDS AS THE ACTIVE INGREDIENT | TEIJIN LTD (JP) | 2005-10-12 | — | — | EP | disclosed |
| EP-1201235-A1 | NEUROPATHY IMPROVERS CONTAINING NITROGENOUS COMPOUNDS AS THE ACTIVE INGREDIENT | TEIJIN LIMITED (JP) | 2002-05-02 | — | — | EP | disclosed |
| US-4692464-A | Novel prostacyclin derivatives and a process for the preparation thereof | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-09-08 | — | — | US | disclosed |
| US-4359581-A | Process for the production of caracyclin intermediates | SCHERING AG (DE) | 1982-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150164853-A1 | PROSTACYCLIN COMPOSITIONS FOR REGULATION OF FRACTURE REPAIR AND BONE FORMATION | PTGIR, PTGIS, PTGS1 | PPARD 847/4885PPARA 649/4885MEN1 4003/4885 |
| US-20170348275-A1 | PROSTACYCLIN COMPOSITIONS FOR REGULATION OF FRACTURE REPAIR AND BONE FORMATION | PTGIR, PTGIS, PTGS1 | PPARD 847/4885PPARA 649/4885MEN1 4003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.