Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 5/20 | 0.36 |
| ▸ | AR | P10275 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173981 | 0.89 | IGF1R (0.40) | ITGALCYP2C9IGF1RARGAA | |
| SCHEMBL6175141 | 0.84 | IGF1R (0.47) | ITGALCYP2C9IGF1RARGAA | |
| SCHEMBL2936726 | 0.83 | IGF1R (0.53) | IGF1R | |
| SCHEMBL6173595 | 0.82 | IGF1R (0.49) | ITGALCYP2C9IGF1RARGAA | |
| SCHEMBL6173800 | 0.82 | ITGAL (0.42) | ITGALCYP2C9IGF1RARTHRB | |
| SCHEMBL6172182 | 0.81 | LMNA (0.44) | ITGALCYP2C9IGF1RARTHRB | |
| SCHEMBL6174831 | 0.80 | IGF1R (0.41) | ITGALCYP2C9IGF1RTHRBKMT2A | |
| SCHEMBL6172219 | 0.80 | MAPT (0.42) | ITGALCYP2C9IGF1RARTHRB | |
| SCHEMBL2942075 | 0.79 | PPARD (0.37) | IGF1RPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2939241 | 0.79 | IGF1R (0.52) | IGF1RMAPTPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |