Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MGAT1 | P26572 | 1/20 | 0.35 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173826 | 0.90 | IGF1R (0.53) | MAPTTHRBIGF1R | |
| SCHEMBL6222480 | 0.90 | MAPT (0.46) | MAPTTHRBCYP2C9ITGALIGF1R | |
| SCHEMBL6173889 | 0.89 | IGF1R (0.50) | ITGALIGF1RKMT2AARTP53 | |
| SCHEMBL6175526 | 0.88 | IGF1R (0.42) | MAPTTHRBITGALIGF1RKMT2A | |
| SCHEMBL6172182 | 0.88 | LMNA (0.44) | MAPTTHRBCYP2C9ITGALIGF1R | |
| SCHEMBL6172714 | 0.86 | IGF1R (0.41) | MAPTTHRBITGALIGF1RKMT2A | |
| SCHEMBL6173800 | 0.85 | ITGAL (0.42) | MAPTTHRBCYP2C9ITGALIGF1R | |
| SCHEMBL6175060 | 0.84 | IGF1R (0.41) | ITGALIGF1RKMT2AARMGAT2 | |
| SCHEMBL6175130 | 0.84 | GRM5 (0.43) | MAPTCYP2C9ITGALIGF1RLMNA | |
| SCHEMBL6174030 | 0.83 | IGF1R (0.39) | CYP2C9ITGALIGF1RLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |