Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173220 | 0.86 | TP53 (0.54) | TP53ALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL6171996 | 0.80 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2HPGDTSHRMAPT | |
| SCHEMBL6168793 | 0.79 | PDE4B (0.46) | ALDH1A1SMN1; SMN2HPGDMAPTLMNA | |
| SCHEMBL6613477 | 0.72 | MAPK1 (0.47) | ALDH1A1SMN1; SMN2HPGDMAPTLMNA | |
| SCHEMBL5795700 | 0.72 | MAPT (0.56) | ALDH1A1SMN1; SMN2HPGDMAPTLMNA | |
| SCHEMBL6963540 | 0.71 | MAPT (0.49) | ALDH1A1SMN1; SMN2HPGDMAPTKDM4E | |
| SCHEMBL3049510 | 0.70 | ADORA2A (0.58) | TP53ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL6173233 | 0.69 | ALDH1A1 (0.82) | TP53ALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL6172259 | 0.69 | TP53 (0.60) | TP53ALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL6610665 | 0.69 | MAPT (0.43) | ALDH1A1SMN1; SMN2MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263757-B1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2005-07-27 | — | — | EP | disclosed |
| EP-1263757-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-11 | — | — | EP | disclosed |
| US-6313116-B1 | PHOSPHODIESTERASE INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2001-11-06 | — | — | US | disclosed |
| WO-2001058897-A1 | BENZTHIAZOLES AS TNF AND PDE-IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |