Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615567 | 0.81 | MAPT (0.44) | HTTALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL6610665 | 0.80 | MAPT (0.43) | HTTALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL6611735 | 0.80 | PIK3CD (0.42) | MAPK1HTTALDH1A1MAPTKDM4E | |
| SCHEMBL6610918 | 0.79 | MAPT (0.52) | ALDH1A1MAPTKDM4EL3MBTL1KMT2A | |
| SCHEMBL6963540 | 0.77 | MAPT (0.49) | ALDH1A1MAPTKDM4EKMT2AMEN1 | |
| SCHEMBL6173003 | 0.72 | TP53 (0.56) | MAPK1ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL5795700 | 0.72 | MAPT (0.56) | HTTALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL6610366 | 0.71 | PIK3CD (0.43) | HTTALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL7253960 | 0.69 | PDE4B (0.52) | ALDH1A1MAPTKDM4EKMT2AHPGD | |
| SCHEMBL6171996 | 0.69 | ALDH1A1 (0.41) | ALDH1A1MAPTKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261605-B1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | DARWIN DISCOVERY LTD (GB) | 2004-11-10 | — | — | EP | disclosed |
| EP-1261605-A1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | Darwin Discovery Limited (GB) | 2002-12-04 | — | — | EP | disclosed |
| US-6403791-B1 | TREATMENT OF INFLAMMATORY DISEASES OR AUTOIMMUNE DISEASES IN HUMANS OR ANIMALS | DARWIN DISCOVERY, LTD. (GB) | 2002-06-11 | — | — | US | disclosed |
| WO-2001058896-A1 | BENZOXAZOLE DERIVATIVES AS TNF AND PDE IV INHIBITORS | DARWIN DISCOVERY LIMITED (GB) | 2001-08-16 | — | — | WO | disclosed |