Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 6/20 | 0.50 |
| ▸ | FNTB | P49356 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | RORC | P51449 | 6/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171808 | 0.84 | FNTA (0.68) | FNTAFNTBCYP3A4RORCCYP19A1 | |
| SCHEMBL6171731 | 0.82 | FNTA (0.47) | FNTAFNTBRORCPGGT1BS1PR1 | |
| SCHEMBL3499579 | 0.81 | FNTA (0.67) | FNTAFNTBCYP3A4RORCPGGT1B | |
| SCHEMBL1683558 | 0.81 | FNTA (0.79) | FNTAFNTBCYP3A4RORC | |
| SCHEMBL4284857 | 0.79 | FNTA (0.55) | FNTAFNTBCYP3A4 | |
| SCHEMBL3527417 | 0.78 | FNTA (0.62) | FNTAFNTBCYP3A4RORCPGGT1B | |
| SCHEMBL4294223 | 0.78 | FNTA (0.60) | FNTAFNTBCYP3A4CYP19A1 | |
| SCHEMBL4294222 | 0.78 | FNTA (0.60) | FNTAFNTBCYP3A4CYP19A1 | |
| SCHEMBL6170592 | 0.78 | RORC (0.47) | RORCS1PR1 | |
| SCHEMBL4301682 | 0.76 | FNTA (0.57) | FNTAFNTBCYP3A4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150973-B1 | HETEROARYL-SUBSTITUTED QUINOLIN-2-ONE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6710209-B2 | INHIBITING FARNESYL PROTEIN TRANSFERASE. | PFIZER INC | 2004-03-23 | — | — | US | disclosed |
| US-20020120145-A1 | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents | PFIZER INC. | 2002-08-29 | — | — | US | disclosed |
| US-6388092-B2 | ANTITUMOR AGENT | PFIZER INC | 2002-05-14 | — | — | US | disclosed |
| US-20020019530-A1 | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents | YANG BINGWEI V (US) | 2002-02-14 | — | — | US | disclosed |
| US-6258824-B1 | TREATMENT OF HYPERPROLIFERATIVE DISEASES, SUCH AS CANCERS, IN MAMMALS. THIS INVENTION ALSO RELATES TO A PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS. | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020120145-A1 | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents | NRAS, CCNA1, KRAS | FNTA 855/4885FNTB 2166/4885CYP3A4 721/4885 |
| US-20020019530-A1 | Heteroaryl-substituted quinolin-2-one derivatives useful as anticancer agents | NRAS, CCNA1, KRAS | FNTA 855/4885FNTB 2166/4885CYP3A4 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.