Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.41 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21803770 | 0.75 | CYP11B1 (0.55) | CYP11B1CYP11B2PTGS2KMT2AMAPT | |
| SCHEMBL1679541 | 0.72 | PTGS2 (0.45) | CYP11B1CYP11B2PTGS2KMT2AMAPT | |
| SCHEMBL1679164 | 0.69 | ERN1 (0.42) | CYP11B1CYP11B2PTGS2KMT2AMAPT | |
| SCHEMBL12615725 | 0.68 | CYP11B1 (0.54) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4214556 | 0.68 | CYP11B1 (0.78) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL29501832 | 0.68 | CYP11B1 (0.78) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1891962 | 0.68 | MAPT (0.49) | CYP11B1CYP11B2PTGS2KMT2AMAPT | |
| SCHEMBL29501870 | 0.68 | CYP11B1 (0.68) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6739910 | 0.67 | — | — | |
| Hydrochloric Acid SCHEMBL8503236 | 0.67 | CYP11B1 (0.76) | CYP11B1CYP11B2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |