Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 10/20 | 0.40 |
| ▸ | BCR | P11274 | 9/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.36 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.36 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.36 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.36 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.36 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.36 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.36 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173825 | 0.89 | MAPK1 (0.42) | IGF1RTP53KMT2A | |
| SCHEMBL6174207 | 0.89 | TSHR (0.35) | IGF1RABL1BCRTP53SMN1; SMN2 | |
| SCHEMBL6171179 | 0.88 | POLB (0.37) | IGF1RTSHRKMT2AATP1A1ATP1B1 | |
| SCHEMBL6172626 | 0.87 | IGF1R (0.40) | IGF1RTSHRKMT2APLK1ATP1A1 | |
| SCHEMBL6172274 | 0.86 | CYP3A4 (0.40) | ABL1MAPKAPK2 | |
| SCHEMBL6174011 | 0.86 | IGF1R (0.56) | IGF1RMAPKAPK2TSHRKMT2A | |
| SCHEMBL6176861 | 0.86 | PDE2A (0.39) | TSHRKMT2AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL6174561 | 0.86 | IGF1R (0.40) | IGF1RTSHRKMT2APLK1 | |
| SCHEMBL6172534 | 0.85 | IGF1R (0.40) | IGF1RABL1BCRTSHRKMT2A | |
| SCHEMBL6176554 | 0.85 | BRAF (0.42) | IGF1RMAPKAPK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |