Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.34 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.34 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.34 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.34 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.34 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.34 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.34 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6170274 | 0.90 | GPR139 (0.35) | TSHRKMT2AABL1BCRSMN1; SMN2 | |
| SCHEMBL6172683 | 0.90 | MAPK1 (0.38) | TSHRKMT2AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL6173261 | 0.89 | IGF1R (0.41) | TSHRKMT2AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL6172534 | 0.88 | IGF1R (0.40) | TSHRKMT2APTGS2ABL1BCR | |
| SCHEMBL6173443 | 0.88 | IGF1R (0.38) | TSHRKMT2APTGS2SMN1; SMN2TP53 | |
| SCHEMBL6173825 | 0.85 | MAPK1 (0.42) | KMT2AEPHX2PTGS2IDH1MAPK1 | |
| SCHEMBL6171179 | 0.84 | POLB (0.37) | TSHRKMT2AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL6172626 | 0.84 | IGF1R (0.40) | TSHRKMT2AATP1A1ATP1B1ATP1A3 | |
| SCHEMBL6172274 | 0.83 | CYP3A4 (0.40) | ABL1MAPK1ALDH1A1PDE2A | |
| SCHEMBL6176861 | 0.82 | PDE2A (0.39) | TSHRKMT2AATP1A1ATP1B1ATP1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |