Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | XIAP | P98170 | 1/20 | 0.32 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171970 | 0.91 | IGF1R (0.41) | IGF1RCYP2C9TRPV3THRBMAPT | |
| SCHEMBL6173179 | 0.87 | IGF1R (0.49) | IGF1RXIAPBIRC2 | |
| SCHEMBL6177675 | 0.79 | SCN10A (0.41) | IGF1RCYP2C9 | |
| SCHEMBL2941543 | 0.76 | IGF1R (0.58) | IGF1R | |
| SCHEMBL6175911 | 0.74 | THRB (0.38) | IGF1RCYP2C9TRPV3CNR1THRB | |
| SCHEMBL6172653 | 0.72 | IGF1R (0.38) | IGF1RXIAPBIRC2 | |
| SCHEMBL6173805 | 0.71 | IGF1R (0.36) | IGF1RTRPV3CNR1THRB | |
| SCHEMBL2942002 | 0.71 | IGF1R (0.45) | IGF1R | |
| SCHEMBL6173800 | 0.69 | ITGAL (0.42) | IGF1RCYP2C9TRPV3THRBMAPT | |
| SCHEMBL6171982 | 0.69 | IGF1R (0.41) | IGF1RCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |