Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131716 | 0.89 | MAPT (0.50) | KMT2ACYP19A1CCR2CYP1A2MAPT | |
| SCHEMBL6172815 | 0.87 | KMT2A (0.49) | KMT2ACYP19A1CCR2CYP1A2CNR2 | |
| SCHEMBL6175680 | 0.85 | EGFR (0.45) | KMT2ACYP19A1CYP1A2CNR2MAPT | |
| SCHEMBL6018883 | 0.81 | CCR2 (0.61) | KMT2ACYP19A1CCR2CYP1A2CNR2 | |
| SCHEMBL9241443 | 0.80 | CCR2 (0.45) | KMT2ACCR2MEN1LMNA | |
| SCHEMBL7076382 | 0.79 | CCR2 (0.51) | KMT2ACCR2MAPTMEN1ALDH1A1 | |
| SCHEMBL6177863 | 0.78 | CCR2 (0.43) | KMT2ACYP19A1CCR2MAPTMEN1 | |
| SCHEMBL6174275 | 0.78 | CCR2 (0.42) | KMT2ACYP19A1CCR2MEN1 | |
| SCHEMBL7071931 | 0.78 | CCR2 (0.72) | CCR2 | |
| SCHEMBL5889460 | 0.77 | MAPT (0.53) | KMT2ACCR2MAPTMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432415-B1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | disclosed |
| EP-1432415-A1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028719-A1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2003-04-10 | — | — | WO | disclosed |