Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.40 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7074174 | 0.88 | CCR2 (0.61) | CCR2PLA2G2AKMT2AMEN1POLB | |
| SCHEMBL7077284 | 0.85 | CCR2 (0.48) | CCR2KMT2AMEN1MAPT | |
| SCHEMBL6308922 | 0.84 | CCR2 (0.71) | CCR2PLA2G2AECE1 | |
| SCHEMBL7071931 | 0.82 | CCR2 (0.72) | CCR2 | |
| SCHEMBL6177863 | 0.81 | CCR2 (0.43) | CCR2PLA2G2AKMT2AMEN1POLB | |
| SCHEMBL6173483 | 0.79 | KMT2A (0.45) | CCR2KMT2AMEN1POLBMAPT | |
| SCHEMBL6174275 | 0.78 | CCR2 (0.42) | CCR2KMT2AMEN1ECE1L3MBTL1 | |
| SCHEMBL8131716 | 0.78 | MAPT (0.50) | CCR2KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL7129310 | 0.78 | CCR2 (0.48) | CCR2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL6172299 | 0.75 | PPARG (0.43) | CCR2KMT2AMEN1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003504-B1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-07-02 | — | — | EP | claimed |