Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.43 |
| ▸ | CCR6 | P51684 | 2/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173978 | 0.92 | CCR6 (0.46) | ABL1SCN9ACCR6OPRM1OPRL1 | |
| SCHEMBL6173342 | 0.85 | ABL1 (0.40) | ABL1ALDH1A1MCHR1ROS1ALK | |
| SCHEMBL6175657 | 0.82 | IGF1R (0.45) | SCN9ANTRK1ITGAL | |
| SCHEMBL6173435 | 0.82 | IGF1R (0.45) | ABL1SCN9AMCHR1NTRK1ITGAL | |
| SCHEMBL6176754 | 0.82 | ITGAL (0.44) | SCN9ANTRK1ITGAL | |
| SCHEMBL2942080 | 0.81 | IGF1R (0.52) | ABL1 | |
| SCHEMBL6172079 | 0.81 | IGF1R (0.47) | ITGAL | |
| SCHEMBL6171047 | 0.81 | IGF1R (0.48) | ALDH1A1NTRK1ITGAL | |
| SCHEMBL6175573 | 0.81 | ITGAL (0.39) | NTRK1ITGAL | |
| SCHEMBL6175755 | 0.80 | ITGAL (0.38) | SCN9AOPRL1NTRK1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |