Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 15/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172303 | 0.91 | ECE1 (0.43) | ECE1MAOBMEN1KMT2AALOX5 | |
| SCHEMBL6175232 | 0.91 | ECE1 (0.47) | ECE1MEN1KMT2AALDH1A1 | |
| SCHEMBL6178305 | 0.90 | RAB9A (0.48) | ECE1MEN1KMT2AALDH1A1 | |
| SCHEMBL6606652 | 0.86 | MEN1 (0.45) | ECE1MEN1KMT2AALOX5ALDH1A1 | |
| SCHEMBL6018607 | 0.86 | ECE1 (0.59) | ECE1 | |
| SCHEMBL6174325 | 0.86 | ECE1 (0.52) | ECE1MEN1KMT2AALDH1A1 | |
| SCHEMBL6176218 | 0.84 | ECE1 (0.47) | ECE1MEN1KMT2AALDH1A1 | |
| SCHEMBL6175560 | 0.82 | ECE1 (0.64) | ECE1 | |
| SCHEMBL6174275 | 0.82 | CCR2 (0.42) | ECE1MEN1KMT2A | |
| SCHEMBL6173011 | 0.81 | KMT2A (0.41) | ECE1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432415-B1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2005-12-28 | — | — | EP | disclosed |
| EP-1432415-A1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028719-A1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2003-04-10 | — | — | WO | disclosed |