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SCHEMBL6173555

SCHEMBL6173555

CC(c1ccnc(C(=O)N2CCCCC2)c1)C1(C(C)c2ccnc(C(=O)N3CCCCC3)c2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.41

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 14/20 0.41
▸ TACR1 P25103 1/20 0.39
▸ PDE2A O00408 4/20 0.39
▸ NPC1 O15118 1/20 0.35
▸ RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6173419 0.93 IGF1R (0.42) IGF1RTACR1PDE2A
SCHEMBL6173405 0.92 IGF1R (0.40) IGF1RTACR1PDE2A
SCHEMBL6173461 0.90 IGF1R (0.39) IGF1RTACR1PDE2A
SCHEMBL6174941 0.87 IGF1R (0.45) IGF1RPDE2A
SCHEMBL6174717 0.87 IGF1R (0.54) IGF1RPDE2A
SCHEMBL6175019 0.87 DPP4 (0.37) IGF1RTACR1
SCHEMBL17558356 0.84 IGF1R (0.56) IGF1RPDE2A
SCHEMBL6176024 0.84 IGF1R (0.41) IGF1RPDE2ANPC1RAB9A
SCHEMBL6174371 0.82 IGF1R (0.44) IGF1RPDE2A
SCHEMBL6174494 0.81 IGF1R (0.42) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed