Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | PREP | P48147 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175941 | 0.92 | PTGS2 (0.39) | DPP4DPP7LMNAMAPK1HTT | |
| SCHEMBL6175494 | 0.90 | IGF1R (0.35) | SMN1; SMN2TACR1IGF1RSCN7AKCNH2 | |
| SCHEMBL6173425 | 0.90 | LMNA (0.38) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6172914 | 0.88 | IGF1R (0.38) | LMNAHTTSMN1; SMN2IGF1RAR | |
| SCHEMBL6173555 | 0.87 | IGF1R (0.41) | TACR1IGF1R | |
| SCHEMBL6259895 | 0.85 | LMNA (0.42) | DPP4DPP7LMNAMAPK1HTT | |
| SCHEMBL6173852 | 0.83 | IGF1R (0.37) | IGF1RARTRPV3CHRNA7KMT2A | |
| SCHEMBL6172497 | 0.82 | IGF1R (0.37) | LMNASMN1; SMN2IGF1RARTRPV3 | |
| SCHEMBL6172419 | 0.81 | HRH4 (0.38) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6201343 | 0.81 | PTGS2 (0.40) | LMNAMAPK1HTTSMN1; SMN2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |