Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171062 | 0.90 | IGF1R (0.35) | IGF1RPDE2ALMNA | |
| SCHEMBL6171361 | 0.90 | IGF1R (0.37) | IGF1RPDE2ALMNA | |
| SCHEMBL6177111 | 0.88 | IGF1R (0.40) | IGF1RPDE2ALMNA | |
| SCHEMBL6173653 | 0.85 | BACE1 (0.38) | IGF1RBACE1PDE2A | |
| SCHEMBL6172238 | 0.85 | KDM4E (0.39) | IGF1RPDE2A | |
| SCHEMBL6174520 | 0.80 | IGF1R (0.38) | IGF1R | |
| SCHEMBL6172631 | 0.79 | IGF1R (0.42) | IGF1RBACE1 | |
| SCHEMBL6172638 | 0.78 | LMNA (0.39) | IGF1RBACE1PDE2ALMNA | |
| SCHEMBL6174700 | 0.76 | IGF1R (0.39) | IGF1R | |
| SCHEMBL6174595 | 0.76 | IGF1R (0.52) | IGF1RPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |