Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 4/20 | 0.36 |
| ▸ | IGF1R | P08069 | 4/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 2/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.32 |
| ▸ | ITGAL | P20701 | 1/20 | 0.32 |
| ▸ | BCL2 | P10415 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175541 | 0.87 | MCHR1 (0.41) | KDM4EGAAL3MBTL1ACHEALDH1A1 | |
| SCHEMBL6171062 | 0.85 | IGF1R (0.35) | PDE2AIGF1RTRPV4 | |
| SCHEMBL6171361 | 0.85 | IGF1R (0.37) | PDE2AIGF1RTRPV4 | |
| SCHEMBL6173736 | 0.85 | IGF1R (0.38) | PDE2AIGF1R | |
| SCHEMBL6177111 | 0.84 | IGF1R (0.40) | PDE2AIGF1R | |
| SCHEMBL6173598 | 0.81 | IGF1R (0.39) | PDE2AIGF1RNPC1RAB9A | |
| SCHEMBL6176997 | 0.81 | KDM4E (0.42) | KDM4EGAAL3MBTL1ACHEALDH1A1 | |
| SCHEMBL6176994 | 0.81 | KDM4E (0.40) | KDM4EGAAL3MBTL1ACHEALDH1A1 | |
| SCHEMBL6171644 | 0.80 | IGF1R (0.33) | PDE2AIGF1RTRPV4NPC1RAB9A | |
| SCHEMBL6176024 | 0.79 | IGF1R (0.41) | PDE2AIGF1RNPC1RAB9AITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |