Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20701414 | 0.82 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL8978249 | 0.82 | HTR2C (0.56) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL17481627 | 0.81 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL7503107 | 0.81 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL7503113 | 0.81 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL28477269 | 0.81 | SMN1; SMN2 (0.49) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL1929718 | 0.78 | HTR2C (0.48) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL29235094 | 0.75 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL20701799 | 0.74 | FAAH (0.48) | NPC1RAB9ASMN1; SMN2GAAMAPK1 | |
| SCHEMBL20701800 | 0.74 | FAAH (0.48) | NPC1RAB9ASMN1; SMN2GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027051-B1 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2005-01-05 | — | — | EP | disclosed |
| US-6391901-B1 | Thrombin inhibitors | ELI LILLY AND COMPANY | 2002-05-21 | — | — | US | disclosed |
| EP-1027051-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-1027051-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-08-16 | — | — | EP | disclosed |
| WO-1998048804-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |