Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK2 | O95069 | 3/20 | 0.44 |
| ▸ | KCNK10 | P57789 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 4/20 | 0.42 |
| ▸ | PDE2A | O00408 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176013 | 0.91 | IGF1R (0.41) | KCNK2IGF1RPDE2ANPC1RAB9A | |
| SCHEMBL6175275 | 0.91 | IGF1R (0.41) | KCNK2KCNK10IGF1RNPC1RAB9A | |
| SCHEMBL6174760 | 0.91 | IGF1R (0.41) | KCNK2KCNK10IGF1RPDE2ANPC1 | |
| SCHEMBL6176337 | 0.87 | NPC1 (0.39) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL6177806 | 0.85 | IGF1R (0.43) | IGF1RPDE2A | |
| SCHEMBL6174274 | 0.83 | GCGR (0.42) | PDE2ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL6177171 | 0.83 | IGF1R (0.46) | IGF1RPDE2AALDH1A1GAA | |
| SCHEMBL6175934 | 0.83 | IGF1R (0.41) | IGF1RNPC1RAB9AALDH1A1TP53 | |
| SCHEMBL6174200 | 0.83 | IGF1R (0.40) | IGF1RPDE2A | |
| SCHEMBL6177584 | 0.83 | IGF1R (0.38) | KCNK2KCNK10IGF1RPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |