Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 2/20 | 0.40 |
| ▸ | KCNK2 | O95069 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175275 | 0.94 | IGF1R (0.41) | IGF1RNPC1RAB9AKCNK2TRPV1 | |
| SCHEMBL6174760 | 0.93 | IGF1R (0.41) | IGF1RNPC1RAB9AKCNK2PDE2A | |
| SCHEMBL6173765 | 0.91 | KCNK2 (0.44) | IGF1RNPC1RAB9AKCNK2MAPK14 | |
| SCHEMBL6177806 | 0.88 | IGF1R (0.43) | IGF1RPDE2A | |
| SCHEMBL6174110 | 0.86 | NPC1 (0.39) | IGF1RNPC1RAB9AHTR1FMAPK14 | |
| SCHEMBL6175934 | 0.85 | IGF1R (0.41) | IGF1RNPC1RAB9A | |
| SCHEMBL6177584 | 0.85 | IGF1R (0.38) | IGF1RKCNK2PDE2A | |
| SCHEMBL6177171 | 0.84 | IGF1R (0.46) | IGF1RPDE2A | |
| SCHEMBL6175915 | 0.84 | IGF1R (0.42) | IGF1RMAPK14PDE2A | |
| SCHEMBL6173796 | 0.84 | IGF1R (0.52) | IGF1RPDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |