Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 2/20 | 0.35 |
| ▸ | PPARD | Q03181 | 3/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.34 |
| ▸ | ELOVL3 | Q9HB03 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177034 | 0.90 | IGF1R (0.40) | IGF1RPTGS2ARITGALPPARD | |
| SCHEMBL6175174 | 0.87 | ABL1 (0.47) | IGF1RPTGS2EPHX2KMT2AL3MBTL1 | |
| SCHEMBL6171765 | 0.87 | IGF1R (0.41) | IGF1RPTGS2AREPHX2KMT2A | |
| SCHEMBL6172261 | 0.86 | IGF1R (0.49) | IGF1RPTGS2AREPHX2ITGAL | |
| SCHEMBL6172594 | 0.86 | AR (0.40) | IGF1RPTGS2AREPHX2ITGAL | |
| SCHEMBL6171575 | 0.85 | IGF1R (0.40) | IGF1RPTGS2ARITGALPPARD | |
| SCHEMBL6173118 | 0.85 | KCNA5 (0.41) | EPHX2SCN9ACYP3A4GAACYP2C9 | |
| SCHEMBL6174845 | 0.84 | NTRK1 (0.38) | PTGS2AREPHX2ITGALPOLB | |
| SCHEMBL6175674 | 0.83 | EPHX2 (0.42) | IGF1RPTGS2AREPHX2ITGAL | |
| SCHEMBL6173776 | 0.82 | IGF1R (0.38) | IGF1RARITGALLIPEELOVL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |