Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 12/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175526 | 0.92 | IGF1R (0.42) | IGF1RARITGALKMT2ATSHR | |
| SCHEMBL6172714 | 0.90 | IGF1R (0.41) | IGF1RARITGALKMT2ATSHR | |
| SCHEMBL6172219 | 0.89 | MAPT (0.42) | IGF1RARITGALKMT2ATP53 | |
| SCHEMBL6175060 | 0.87 | IGF1R (0.41) | IGF1RARITGALKMT2ATSHR | |
| SCHEMBL6169398 | 0.86 | IGF1R (0.49) | IGF1RARITGALKMT2AKIF11 | |
| SCHEMBL6173575 | 0.85 | IGF1R (0.44) | IGF1RARITGALKMT2ATSHR | |
| SCHEMBL6175372 | 0.84 | IGF1R (0.41) | IGF1RARKMT2A | |
| SCHEMBL6174483 | 0.83 | IGF1R (0.42) | IGF1RARITGALKMT2ATSHR | |
| SCHEMBL6175004 | 0.83 | IGF1R (0.42) | IGF1RARITGALKMT2ATSHR | |
| SCHEMBL6176511 | 0.83 | NAMPT (0.43) | IGF1RKITBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |