Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172453 | 0.93 | IGF1R (0.40) | IGF1RMAPTPKMALDH1A1GAA | |
| SCHEMBL6174414 | 0.90 | IGF1R (0.38) | IGF1RMAPTMAPK14PIK3C3PKM | |
| SCHEMBL6173886 | 0.88 | IGF1R (0.40) | IGF1RPIK3C3ALDH1A1GAAAR | |
| SCHEMBL6172735 | 0.87 | IGF1R (0.42) | IGF1RMAPTMAPK14ALDH1A1GAA | |
| SCHEMBL6177168 | 0.86 | IGF1R (0.56) | IGF1RMAPT | |
| SCHEMBL6174108 | 0.85 | NPC1 (0.39) | IGF1RMAPK14ALDH1A1GAAAR | |
| SCHEMBL6176511 | 0.85 | NAMPT (0.43) | IGF1RMAPK14 | |
| SCHEMBL6172182 | 0.85 | LMNA (0.44) | IGF1RMAPTALDH1A1GAAAR | |
| SCHEMBL6176335 | 0.84 | CYP3A4 (0.46) | IGF1RMAPTMAPK14PKMALDH1A1 | |
| SCHEMBL6173889 | 0.84 | IGF1R (0.50) | IGF1RARKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |