Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | GALR2 | O43603 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.33 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174879 | 0.87 | IGF1R (0.40) | PDE2A | |
| SCHEMBL6173358 | 0.84 | CCR6 (0.43) | CCR6SCN9AGPR139PDE2AMCHR1 | |
| SCHEMBL6175237 | 0.77 | CCR6 (0.43) | CCR6SCN9AGPR139PDE2AMCHR1 | |
| SCHEMBL2940053 | 0.76 | LTA4H (0.40) | MCHR1ABL1 | |
| SCHEMBL2935236 | 0.75 | CCR6 (0.42) | CCR6SCN9AMCHR1GALR2ABL1 | |
| SCHEMBL6173980 | 0.71 | CCR6 (0.42) | CCR6SCN9AGPR139PDE2AMCHR1 | |
| SCHEMBL2940698 | 0.70 | ABL1 (0.46) | CCR6SCN9AMCHR1ABL1 | |
| SCHEMBL2940588 | 0.69 | ABL1 (0.46) | SCN9AMCHR1ABL1 | |
| SCHEMBL2937083 | 0.68 | IGF1R (0.52) | CCR6 | |
| SCHEMBL2940003 | 0.68 | HCRTR1 (0.44) | CCR6SCN9AMCHR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |