Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.37 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.34 |
| ▸ | ITGAL | P20701 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173490 | 0.92 | ABL1 (0.44) | CCR6SCN9ALMNAMCHR1LRRK2 | |
| SCHEMBL6175676 | 0.84 | EPHX2 (0.44) | PDE2ALMNAMCHR1 | |
| SCHEMBL6175578 | 0.83 | LMNA (0.42) | PDE2ALMNAMCHR1GPR139POLB | |
| SCHEMBL6173438 | 0.83 | LMNA (0.42) | PDE2ALMNAMCHR1ABL1POLB | |
| SCHEMBL6176756 | 0.83 | LMNA (0.42) | PDE2ALMNAMCHR1POLBL3MBTL1 | |
| SCHEMBL6172084 | 0.81 | LMNA (0.40) | PDE2ALMNAMCHR1GPR139POLB | |
| SCHEMBL6175660 | 0.81 | LMNA (0.40) | LMNAMCHR1GPR139POLBL3MBTL1 | |
| SCHEMBL6171053 | 0.81 | LMNA (0.40) | PDE2ALMNAMCHR1POLBL3MBTL1 | |
| SCHEMBL6177038 | 0.81 | LMNA (0.42) | PDE2ALMNAMCHR1GPR139POLB | |
| SCHEMBL6174848 | 0.80 | LMNA (0.46) | PDE2ALMNAPOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |