6-O-Benzylguanine

6-O-Benzylguanine

SCHEMBL61740

Nc1nc(OCc2ccccc2)c2[nH]cnc2n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PIN1 Q13526 9/20 1.00
MGMT P16455 9/20 1.00
CDK1 P06493 7/20 1.00
CCNB1 P14635 7/20 1.00
CCNA2 P20248 7/20 1.00
CDK2 P24941 7/20 1.00
CCNA1 P78396 7/20 1.00
CYP3A4 P08684 2/20 1.00
LMNA P02545 1/20 1.00
CYP1A2 P05177 1/20 1.00
CYP2D6 P10635 1/20 1.00
CYP2C9 P11712 1/20 1.00
TSHR P16473 1/20 1.00
NFKB1 P19838 1/20 1.00
CYP2C19 P33261 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
CDC7 O00311 1/20 0.63
DBF4 Q9UBU7 1/20 0.63
MPO P05164 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-O-Benzylguanine SCHEMBL31517079 1.00 PIN1 (1.00) PIN1MGMTCDK1CCNB1CCNA2
6-O-Benzylguanine SCHEMBL4631744 0.99 PIN1 (0.97) PIN1MGMTCDK1CCNB1CCNA2
6-O-Benzylguanine SCHEMBL4869639 0.94 PIN1 (0.88) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL851965 0.88 PIN1 (0.78) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL23124359 0.87 MGMT (0.81) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL29749175 0.87 MGMT (0.81) PIN1MGMTCDK1CCNB1CCNA2
6-O-Benzylguanine SCHEMBL10916361 0.87 PIN1 (0.76) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL3302326 0.86 PIN1 (1.00) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL3338895 0.86 PIN1 (0.76) PIN1MGMTCDK1CCNB1CCNA2
SCHEMBL3302852 0.86 PIN1 (0.76) PIN1MGMTCDK1CCNB1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6806 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121717922-B Antibody-BPA protein-nucleic acid tag compound and preparation method and application thereof HUAZHONG AGRICULTURAL UNIVERSITY (CN) 2026-05-26 CN claimed
WO-2026102435-A1 METHODS OF NUCLEIC ACID PROCESSING AND SYNTHESIS UNIVERSITY OF MASSACHUSETTS (US) 2026-05-15 WO claimed
US-12577255-B2 MDM2-based modulators of proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-03-17 US claimed
US-20260071270-A1 ON-SEQUENCER IMAGING FLOWCELL REUSE ILLUMINA, INC. (US) 2026-03-12 US claimed
EP-4704832-A2 BIFUNCTIONAL SMALL MOLECULES TO TARGET THE SELECTIVE DEGRADATION OF CIRCULATING PROTEINS Biohaven Therapeutics Ltd. (VG) 2026-03-11 EP claimed
US-20260022117-A1 COMPOUNDS AND METHODS FOR THE ENHANCED DEGRADATION OF TARGETED PROTEINS ARVINAS OPERATIONS INC (US) 2026-01-22 US claimed
US-20260015402-A1 SMALL MOLECULE ADAPTER REGULATED, TARGET SPECIFIC CHIMERIC ANTIGEN RECEPTOR BEARING T CELLS (SMART CARS) YALE UNIVERSITY 2026-01-15 US claimed
EP-4678764-A2 NANOPARTICLE WITH SINGLE SITE FOR TEMPLATE POLYNUCLEOTIDE ATTACHMENT ILLUMINA, INC. (US) 2026-01-14 EP claimed
US-12485178-B2 Bifunctional small molecules to target the selective degradation of circulating proteins YALE UNIVERSITY (US) 2025-12-02 US claimed
US-20250333696-A1 DNA-CHIMERIC ANTIGEN RECEPTOR T CELLS FOR IMMUNOTHERAPY UNIV ARIZONA STATE (US) 2025-10-30 US claimed
WO-2004052310-A2 PROCESS AND INTERMEDIATES FOR SYNTHESIS ENTECAVIR BRISTOL-MYERS SQUIBB COMPANY (US) 2004-06-24 WO claimed
US-20040092583-A1 Treatment for inhibiting neoplastic lesions SHANAHAN-PRENDERGAST ELIZABETH (IE) 2004-05-13 US claimed
WO-2003084957-A1 CRYSTAL AND SOLVATE OF 2-AMINO-6-BENZYLOXYPURINE AND PRODUCTION METHODS THEREOF SUMIKA FINE CHEMICALS CO., LTD. (JP) 2003-10-16 WO claimed
EP-1351678-A2 TREATMENT FOR INHIBITING NEOPLASTIC LESIONS USING INCENSOLE AND/OR FURANOGERMACRENS Shanahan-Prendergast, Elizabeth (IE) 2003-10-15 EP claimed
WO-2002053138-A2 TREATMENT FOR INHIBITING NEOPLASTIC LESIONS USING INCENSOLE AND/OR FURANOGERMACRENS SHANAHAN-PRENDERGAST ELISABETH (IE) 2002-07-11 WO claimed
EP-1054890-A1 OLIGODEOXYRIBONUCLEOTIDES COMPRISING O6-BENZYLGUANINE AND THEIR USE THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 2000-11-29 EP claimed
WO-1999041269-A1 OLIGODEOXYRIBONUCLEOTIDES COMPRISING O6-BENZYLGUANINE AND THEIR USE THE UNITED STATES OF AMERICA, REPRESENTED BY SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1999-08-19 WO claimed
US-5064961-A PROCESS FOR PREPARING AN OPTICALLY ACTIVE CYCLOBUTANE NUCLEOSIDE E. R. SQUIBB & SONS, INC. (US) 1991-11-12 US claimed
US-4801710-A Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO., INC. (US) 1989-01-31 US claimed
EP-0184473-A1 Regioselective synthesis of 9-substituted purine acyclonucleoside derivatives MERCK & CO. INC. (US) 1986-06-11 EP claimed