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SCHEMBL6174100

SCHEMBL6174100

CNc1cnc2ccccc2c1C(C)C1(C(C)c2c(NC)cnc3ccccc23)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 16/20 0.36
▸ NTRK1 P04629 1/20 0.32
▸ AR P10275 1/20 0.32
▸ LMNA P02545 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6174520 0.88 IGF1R (0.38) IGF1RNTRK1AR
SCHEMBL6174509 0.87 IGF1R (0.39) IGF1RNTRK1ARLMNATSHR
SCHEMBL6174684 0.86 P2RX3 (0.35) IGF1RAR
SCHEMBL6175506 0.85 IGF1R (0.45) IGF1RARLMNATSHRKMT2A
SCHEMBL6171644 0.83 IGF1R (0.33) IGF1RNTRK1AR
SCHEMBL6177111 0.80 IGF1R (0.40) IGF1RLMNATSHRKMT2A
SCHEMBL6174268 0.78 IGF1R (0.39) IGF1RTSHRKMT2A
SCHEMBL6176288 0.78 IGF1R (0.39) IGF1RNTRK1
SCHEMBL6171361 0.76 IGF1R (0.37) IGF1RLMNATSHRKMT2A
SCHEMBL6171062 0.76 IGF1R (0.35) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed