Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 10/20 | 0.33 |
| ▸ | PDE2A | O00408 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 2/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174520 | 0.85 | IGF1R (0.38) | IGF1RNTRK1AR | |
| SCHEMBL6174509 | 0.84 | IGF1R (0.39) | IGF1RNTRK1AR | |
| SCHEMBL6174100 | 0.83 | IGF1R (0.36) | IGF1RNTRK1AR | |
| SCHEMBL6174684 | 0.83 | P2RX3 (0.35) | IGF1RAR | |
| SCHEMBL6172238 | 0.80 | KDM4E (0.39) | IGF1RPDE2ANPC1RAB9ATRPV4 | |
| SCHEMBL6171343 | 0.80 | IGF1R (0.36) | IGF1RPDE2ANPC1RAB9A | |
| SCHEMBL6172470 | 0.80 | IGF1R (0.36) | IGF1RPDE2ANPC1RAB9ANTRK1 | |
| SCHEMBL6173598 | 0.76 | IGF1R (0.39) | IGF1RPDE2ANPC1RAB9A | |
| SCHEMBL6176024 | 0.75 | IGF1R (0.41) | IGF1RPDE2ANPC1RAB9A | |
| SCHEMBL2940151 | 0.74 | IGF1R (0.52) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |