Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175564 | 0.79 | LMNA (0.39) | IGF1RSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL2938212 | 0.75 | IGF1R (0.40) | IGF1RSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL6173929 | 0.75 | IGF1R (0.36) | CA12CA1CA2CA9IGF1R | |
| SCHEMBL6202665 | 0.73 | SMN1; SMN2 (0.42) | CA12CA1CA2CA9IGF1R | |
| SCHEMBL6172452 | 0.72 | HTT (0.36) | CA12CA1CA2CA9IGF1R | |
| SCHEMBL6184115 | 0.72 | CYP3A4 (0.36) | IGF1RSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL2935040 | 0.71 | CYP3A4 (0.37) | IGF1RSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL2933093 | 0.70 | IGF1R (0.39) | IGF1RSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL6173546 | 0.67 | KMT2A (0.36) | IGF1RSMN1; SMN2LMNAMAPK1HTT | |
| SCHEMBL6174716 | 0.67 | KMT2A (0.36) | IGF1RSMN1; SMN2LMNAMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |