Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172891 | 0.87 | CCR6 (0.34) | ALDH1A1DPP4DPP7CYP3A4GAA | |
| SCHEMBL6202665 | 0.80 | SMN1; SMN2 (0.42) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6174181 | 0.79 | CA12 (0.35) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6175001 | 0.77 | LMNA (0.40) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6172452 | 0.74 | HTT (0.36) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6170701 | 0.71 | IGF1R (0.37) | IGF1RALDH1A1CYP3A4GAACYP2C9 | |
| SCHEMBL2932317 | 0.70 | IGF1R (0.60) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6174638 | 0.70 | IGF1R (0.43) | SMN1; SMN2IGF1RALDH1A1CYP3A4GAA | |
| SCHEMBL2938212 | 0.69 | IGF1R (0.40) | LMNAMAPK1HTTSMN1; SMN2IGF1R | |
| SCHEMBL6174716 | 0.69 | KMT2A (0.36) | LMNAMAPK1HTTSMN1; SMN2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |