Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.46 |
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 6/20 | 0.52 |
| ▸ | ESR1 | P03372 | 13/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PLD2 | O14939 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | C5 | P01031 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174072 | 0.89 | ENPP3 (0.47) | F2ESR1ESR2ALDH1A1 | |
| Oxalic Acid SCHEMBL6173105 | 0.87 | F2 (0.70) | F2TSHR | |
| SCHEMBL6172358 | 0.85 | F2 (0.70) | F2TSHR | |
| SCHEMBL6172000 | 0.81 | ESR1 (0.61) | F2ESR1ESR2MEN1PLD2 | |
| SCHEMBL6597230 | 0.80 | F2 (0.73) | F2ESR1ESR2MEN1PLD2 | |
| SCHEMBL6171170 | 0.79 | ESR1 (0.59) | F2ESR1ESR2MEN1PLD2 | |
| SCHEMBL6596053 | 0.79 | ESR1 (0.79) | F2ESR1ESR2MEN1PLD2 | |
| SCHEMBL7323038 | 0.76 | F2 (0.59) | F2ESR1ESR2MEN1PLD2 | |
| SCHEMBL7323044 | 0.76 | F2 (0.59) | F2ESR1ESR2MEN1PLD2 | |
| SCHEMBL7819814 | 0.76 | GAA (0.51) | F2MEN1ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1027051-B1 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2005-01-05 | — | — | EP | disclosed |
| US-6391901-B1 | Thrombin inhibitors | ELI LILLY AND COMPANY | 2002-05-21 | — | — | US | disclosed |