Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.86 |
| ▸ | TP53 | P04637 | 10/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.76 |
| ▸ | RAB9A | P51151 | 9/20 | 0.76 |
| ▸ | NPC1 | O15118 | 9/20 | 0.76 |
| ▸ | PKM | P14618 | 8/20 | 0.76 |
| ▸ | TSHR | P16473 | 6/20 | 0.72 |
| ▸ | MAPT | P10636 | 5/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | MITF | O75030 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187023 | 0.93 | GRM5 (1.00) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5959953 | 0.87 | PKM (1.00) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4198173 | 0.83 | GRM5 (1.00) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| Dimethylamine SCHEMBL4192736 | 0.81 | PKM (0.88) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL30821175 | 0.80 | GRM5 (1.00) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4190470 | 0.78 | GRM5 (1.00) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4195323 | 0.77 | GRM5 (1.00) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4186570 | 0.77 | TP53 (0.74) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL9505522 | 0.76 | NPC1 (0.70) | GRM5TP53SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1424895 | 0.76 | TP53 (0.77) | GRM5TP53SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210344-B1 | HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | NPS PHARMA INC (US) | 2005-10-19 | — | — | EP | claimed |