Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.65 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.65 |
| ▸ | RAF1 | P04049 | 8/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.55 |
| ▸ | BRAF | P15056 | 9/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.41 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222724 | 0.93 | CSNK1A1 (0.55) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6172475 | 0.92 | CSNK1A1 (0.54) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6171469 | 0.91 | MAPK14 (0.70) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6171462 | 0.91 | MAPK14 (0.70) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6172307 | 0.91 | MAPK14 (0.70) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6170268 | 0.90 | MAPK14 (0.72) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6172458 | 0.89 | MAPK13 (0.64) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL14174029 | 0.89 | MAPK14 (0.51) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6170576 | 0.89 | MAPK14 (0.49) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 | |
| SCHEMBL6170828 | 0.88 | MAPK13 (0.49) | CSNK1A1CSNK1DRPS6KA3RAF1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080139596-A1 | Modulators of Hcv Replication | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-06-12 | — | — | US | disclosed |
| US-20080139596-A1 | Modulators of Hcv Replication | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2008-06-12 | — | — | US | disclosed |
| EP-0906307-B1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-0906307-A4 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO INC (US) | 2002-05-29 | — | — | EP | disclosed |
| EP-0906307-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | Merck & Co., Inc. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997047618-A1 | SUBSTITUTED IMIDAZOLES HAVING CYTOKINE INHIBITORY ACTIVITY | MERCK & CO., INC. (US) | 1997-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139596-A1 | Modulators of Hcv Replication | EIF2AK2, MAVS, IRF3 | CSNK1A1 1939/4885CSNK1D 2168/4885RPS6KA3 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.