Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174137 | 0.88 | CYP2C9 (0.36) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6171796 | 0.87 | IGF1R (0.36) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6173613 | 0.85 | KIF11 (0.37) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6175647 | 0.85 | ALDH1A1 (0.38) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6175557 | 0.83 | GAA (0.36) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6170996 | 0.83 | CYP3A4 (0.50) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6173386 | 0.82 | ALDH1A1 (0.41) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6175558 | 0.82 | RXFP1 (0.35) | GAACYP2C19ALDH1A1RXFP1NAMPT | |
| SCHEMBL6172506 | 0.82 | NAMPT (0.40) | GAACYP2C9CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL6171051 | 0.82 | NAMPT (0.48) | CYP2C9NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |