Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 1/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 7/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414121 | 0.92 | ACVR2A (0.53) | ACVR2ATGFBR2ROCK2MAPK1NAMPT | |
| SCHEMBL412981 | 0.77 | ACVR2A (0.53) | ACVR2ATGFBR2NAMPTL3MBTL1ALDH1A1 | |
| SCHEMBL414392 | 0.75 | ACVR2A (0.76) | ACVR2ATGFBR2NAMPTL3MBTL1ATM | |
| SCHEMBL409761 | 0.74 | ACVR2A (0.47) | ACVR2ATGFBR2RORCMEN1ALDH1A1 | |
| SCHEMBL3424283 | 0.74 | ACVR2A (0.64) | ACVR2ATGFBR2NAMPTL3MBTL1ATM | |
| SCHEMBL412983 | 0.66 | ACVR2A (0.40) | ACVR2ATGFBR2KCNA5RORCMEN1 | |
| SCHEMBL21932072 | 0.63 | ACVR2A (0.80) | ACVR2ATGFBR2ROCK2NAMPTL3MBTL1 | |
| SCHEMBL411189 | 0.62 | ACVR2A (0.79) | ACVR2ATGFBR2NAMPTL3MBTL1MEN1 | |
| SCHEMBL411369 | 0.61 | ACVR2A (1.00) | ACVR2ATGFBR2NAMPTL3MBTL1ALDH1A1 | |
| SCHEMBL28872280 | 0.59 | HIF1A (0.54) | ROCK2MEN1ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590347-A1 | ISOTHIAZOLE DERIVATIVES | Pfizer Products Inc. (US) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004067530-A1 | ISOTHIAZOLE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2004-08-12 | — | — | WO | disclosed |