Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412981 | 0.82 | ACVR2A (0.53) | ACVR2ATGFBR2MAPTALDH1A1KMT2A | |
| SCHEMBL409761 | 0.81 | ACVR2A (0.47) | ACVR2ATGFBR2RORCMAPTCYP17A1 | |
| SCHEMBL414121 | 0.73 | ACVR2A (0.53) | ACVR2ATGFBR2KMT2A | |
| SCHEMBL3081967 | 0.67 | NTRK1 (0.39) | ACVR2ATGFBR2MAPTNTRK1ALDH1A1 | |
| SCHEMBL6174538 | 0.66 | ACVR2A (0.44) | ACVR2ATGFBR2RORCKCNA5ALDH1A1 | |
| SCHEMBL3078380 | 0.64 | ACVR2A (0.50) | ACVR2ATGFBR2MAPTNOX1ALDH1A1 | |
| SCHEMBL3096057 | 0.63 | RAB9A (0.43) | ACVR2ATGFBR2MAPTALDH1A1MEN1 | |
| SCHEMBL3359466 | 0.63 | ACVR2A (0.42) | ACVR2ATGFBR2NTRK1ALDH1A1 | |
| SCHEMBL3078751 | 0.63 | ACVR2A (0.43) | ACVR2ATGFBR2NTRK1ALDH1A1 | |
| SCHEMBL412782 | 0.63 | ACVR2A (0.71) | ACVR2ATGFBR2NTRK1ALDH1A1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140120621-A1 | TGF-BETA RECEPTOR INHIBITORS TO ENHANCE DIRECT REPROGRAMMING | THE GENERAL HOSPITAL CORPORATION (US) | 2014-05-01 | — | — | US | disclosed |
| US-8603818-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2013-12-10 | — | — | US | disclosed |
| US-8298825-B1 | TGF-beta receptor inhibitors to enhance direct reprogramming | THE GENERAL HOSPITAL CORPORATION (US) | 2012-10-30 | — | — | US | disclosed |
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |