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SCHEMBL6174667

SCHEMBL6174667

CC(c1c(N)cnc2ccccc12)C1NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 1/20 0.36
▸ IGF1R P08069 13/20 0.35
▸ NTRK1 P04629 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6175139 0.91 LMNA (0.38) LMNAIGF1RNTRK1SMN1; SMN2
SCHEMBL6174256 0.89 LMNA (0.36) LMNAIGF1RSMN1; SMN2
SCHEMBL6172848 0.88 LMNA (0.38) LMNAIGF1R
SCHEMBL6173669 0.85 IGF1R (0.46) LMNAIGF1R
SCHEMBL6172638 0.80 LMNA (0.39) LMNAIGF1R
SCHEMBL6174520 0.78 IGF1R (0.38) IGF1RNTRK1
SCHEMBL6175291 0.78 IGF1R (0.36) LMNAIGF1RSMN1; SMN2
SCHEMBL6175754 0.77 LMNA (0.39) LMNAIGF1R
SCHEMBL6175824 0.77 LMNA (0.39) LMNAIGF1R
SCHEMBL6171605 0.76 LMNA (0.39) LMNAIGF1RSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed