Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 9/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 5/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175824 | 0.91 | LMNA (0.39) | LMNAARIGF1RTRPV4PDE2A | |
| SCHEMBL6172638 | 0.90 | LMNA (0.39) | LMNAARIGF1RTRPV4PDE2A | |
| SCHEMBL6171605 | 0.90 | LMNA (0.39) | LMNAARIGF1RTRPV4PDE2A | |
| SCHEMBL6175015 | 0.89 | LMNA (0.38) | LMNAARIGF1RTRPV4PDE2A | |
| SCHEMBL6176997 | 0.86 | KDM4E (0.42) | LMNAARTRPV4PDE2A | |
| SCHEMBL6174264 | 0.84 | IGF1R (0.43) | LMNAARIGF1R | |
| SCHEMBL6173610 | 0.79 | IGF1R (0.37) | LMNAIGF1R | |
| SCHEMBL6175139 | 0.79 | LMNA (0.38) | LMNAIGF1RTRPV4 | |
| SCHEMBL6171361 | 0.78 | IGF1R (0.37) | LMNAIGF1RTRPV4PDE2A | |
| SCHEMBL6174667 | 0.77 | LMNA (0.36) | LMNAIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |