Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5827942 | 0.99 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6172483 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL5827358 | 0.91 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL12870032 | 0.80 | ACHE (0.76) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6174219 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL5827423 | 0.79 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL1143175 | 0.79 | ACHE (0.74) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6172196 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6173395 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL5827256 | 0.76 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170288-B9 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2005-01-26 | — | — | EP | disclosed |
| EP-1170288-B1 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| EP-1170288-A2 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |