Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.48 |
| ▸ | ITGAV | P06756 | 3/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.48 |
| ▸ | UBE2N | P61088 | 1/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CFB | P00751 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5827423 | 0.99 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6173769 | 0.88 | NPC1 (0.51) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL5827404 | 0.87 | NPC1 (0.50) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL5828141 | 0.87 | NPC1 (0.50) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL5827392 | 0.86 | NPC1 (0.49) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL12870032 | 0.84 | ACHE (0.76) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| Hydrochloric Acid SCHEMBL1143175 | 0.83 | ACHE (0.74) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6172196 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6174772 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1MEN1KMT2ARAB9A | |
| SCHEMBL6173395 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170288-B9 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2005-01-26 | — | — | EP | disclosed |
| EP-1170288-B1 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| EP-1170288-A2 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |