Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22393709 | 0.83 | TDP1 (0.47) | FDPSTDP1HTTCYP11B1CYP11B2 | |
| SCHEMBL6175276 | 0.82 | FDPS (0.46) | FDPSTDP1HTTCYP11B1CYP11B2 | |
| SCHEMBL2614317 | 0.78 | NPC1 (0.49) | FDPSTDP1HTTCYP11B1CYP11B2 | |
| SCHEMBL19738704 | 0.77 | TDP1 (0.44) | FDPSTDP1HTTCYP11B1CYP11B2 | |
| SCHEMBL18714716 | 0.77 | TDP1 (0.44) | FDPSTDP1HTTCYP11B1CYP11B2 | |
| SCHEMBL11578320 | 0.75 | NPC1 (0.43) | FDPSTDP1APAF1MAPTHPGD | |
| SCHEMBL14268957 | 0.74 | ALDH1A1 (0.47) | FDPSHTTAPAF1MAPTHPGD | |
| SCHEMBL2164037 | 0.74 | EGLN3 (0.45) | FDPSAPAF1MAPTHPGDHSD17B10 | |
| SCHEMBL4013913 | 0.73 | FDPS (0.46) | FDPSTDP1HTTAPAF1HPGD | |
| SCHEMBL3796582 | 0.73 | SMN1; SMN2 (0.44) | FDPSTDP1HTTAPAF1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392280-A4 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1392280-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | Abbott GmbH & Co. KG (DE) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002089749-A2 | ARYLSULFONAMIDE ETHERS, AND METHODS OF USE THEREOF | ABBOTT GMBH & CO.KG (DE) | 2002-11-14 | — | — | WO | disclosed |