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Sugi Predict / Compounds / SCHEMBL6174980

SCHEMBL6174980

SCHEMBL6174980

CC(c1ccnc2c(Cl)cccc12)C1NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.36

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 16/20 0.36
▸ LMNA P02545 1/20 0.34
▸ TRPV4 Q9HBA0 1/20 0.33
▸ NTRK1 P04629 1/20 0.31
▸ NR4A2 P43354 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6174880 0.88 IGF1R (0.36) IGF1RLMNATRPV4NTRK1
SCHEMBL6171781 0.88 P2RX3 (0.36) IGF1RLMNA
SCHEMBL6174021 0.86 IGF1R (0.36) IGF1RLMNA
SCHEMBL6171030 0.86 LMNA (0.40) LMNATRPV4
SCHEMBL6173471 0.85 IGF1R (0.42) IGF1RLMNANR4A2
SCHEMBL6174287 0.83 IGF1R (0.38) IGF1RLMNANR4A2
SCHEMBL6173954 0.80 IGF1R (0.36) IGF1RLMNA
SCHEMBL6173610 0.79 IGF1R (0.37) IGF1RLMNA
SCHEMBL6176324 0.79 IGF1R (0.35) IGF1RLMNATRPV4
SCHEMBL6174393 0.79 SMN1; SMN2 (0.43) IGF1RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed