SCHEMBL6175342

SCHEMBL6175342

FC(F)(F)c1cnc(-c2ccc(Cl)cc2)c(Cl)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 11/20 0.64
SMN1; SMN2 Q16637 6/20 0.64
KDM4E B2RXH2 5/20 0.64
POLB P06746 3/20 0.64
NPC1 O15118 5/20 0.60
RAB9A P51151 5/20 0.60
MAPT P10636 3/20 0.60
HTT P42858 2/20 0.60
MAPK1 P28482 1/20 0.56
RXFP1 Q9HBX9 1/20 0.56
NPSR1 Q6W5P4 3/20 0.52
PKM P14618 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.50
MEN1 O00255 1/20 0.47
STAT3 P40763 1/20 0.47
STAT1 P42224 1/20 0.47
CASP3 P42574 1/20 0.47
KMT2A Q03164 1/20 0.47
SENP8 Q96LD8 1/20 0.47
SENP7 Q9BQF6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176543 0.88 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL6977861 0.87 ALDH1A1 (0.60) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL6975261 0.83 MEN1 (0.60) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL6177938 0.82 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL4182244 0.82 NPC1 (0.56) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL4177078 0.81 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL6177219 0.81 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL8006677 0.81 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL6173806 0.81 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1
SCHEMBL8664491 0.81 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2KDM4EPOLBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105712926-B Substituted biaryl perfume base benzenesulfonamides and application thereof 沈阳中化农药化工研发有限公司 2019-01-04 CN disclosed
CN-105712925-B A kind of substituted sulfoamido (thio) carbonyls and application thereof 沈阳中化农药化工研发有限公司 2019-01-04 CN disclosed
CN-105712926-A Substituted biaryl benzenesulfonamide compound and application thereof 沈阳中化农药化工研发有限公司 2016-06-29 CN disclosed
CN-105712925-A Substituted sulfamine (sulfo-) carbonyl compound and application thereof 沈阳中化农药化工研发有限公司 2016-06-29 CN disclosed
EP-0708756-B1 SUBSTITUTED 2-PHENYLPYRIDINES WITH HERBICIDAL ACTION BASF AG (DE) 2005-06-01 EP disclosed
US-5783522-A HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-07-21 US disclosed
CN-1127504-A Substituted 2-phenylpyridines with herbicidal action BASF AG (DE) 1996-07-24 CN disclosed
EP-0708756-A1 SUBSTITUTED 2-PHENYLPYRIDINES WITH HERBICIDAL ACTION BASF AKTIENGESELLSCHAFT (DE) 1996-05-01 EP disclosed
WO-1995002580-A2 SUBSTITUTED 2-PHENYLPYRIDINES WITH HERBICIDAL ACTION BASF AKTIENGESELLSCHAFT (DE) 1995-01-26 WO disclosed