Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CBFB | Q13951 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.35 |
| ▸ | GPR39 | O43194 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173621 | 0.86 | IGF1R (0.42) | TSHRKMT2AAR | |
| SCHEMBL6171903 | 0.85 | IGF1R (0.45) | ALDH1A1TSHRKMT2ACYP3A4GAA | |
| SCHEMBL6174749 | 0.84 | AR (0.38) | ALDH1A1TSHRKMT2ACYP3A4GAA | |
| SCHEMBL6172098 | 0.83 | AR (0.37) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173695 | 0.82 | ITGAL (0.40) | ALDH1A1KMT2ACYP3A4GAACYP2C9 | |
| SCHEMBL6170776 | 0.82 | DGAT2 (0.38) | ALDH1A1KCNH2ABL1ARCYP11B1 | |
| SCHEMBL6173349 | 0.82 | ALDH1A1 (0.39) | ALDH1A1FLT1KDRCYP3A4GAA | |
| SCHEMBL6175943 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KMT2AFLT1KDRCYP3A4 | |
| SCHEMBL6172435 | 0.82 | POLB (0.38) | ALDH1A1CYP3A4GAACYP2C9CYP2C19 | |
| SCHEMBL6173183 | 0.81 | CYP3A4 (0.39) | ALDH1A1FLT1KDRCYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |