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SCHEMBL6175664

SCHEMBL6175664

CC(c1ccnc(NS(=O)(=O)NCc2ccccc2)c1)C1(C(C)c2ccnc(NS(=O)(=O)NCc3ccccc3)c2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 19/20 0.47
▸ MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6173711 0.89 IGF1R (0.59) IGF1R
SCHEMBL6175730 0.88 IGF1R (0.38) IGF1RMAPK1
SCHEMBL6172683 0.88 MAPK1 (0.38) IGF1RMAPK1
SCHEMBL6173885 0.87 IGF1R (0.44) IGF1R
SCHEMBL17558349 0.86 IGF1R (0.56) IGF1R
SCHEMBL6174011 0.84 IGF1R (0.56) IGF1R
SCHEMBL6177313 0.83 IGF1R (0.45) IGF1R
SCHEMBL6176345 0.83 IGF1R (0.53) IGF1R
SCHEMBL6175947 0.82 IGF1R (0.46) IGF1R
SCHEMBL6173508 0.82 IGF1R (0.56) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed