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SCHEMBL17558349

SCHEMBL17558349

CC(c1ccnc(NS(C)(=O)=O)c1)C1(C(C)c2ccnc(NS(C)(=O)=O)c2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 19/20 0.56
▸ PDE2A O00408 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6173885 0.89 IGF1R (0.44) IGF1R
SCHEMBL6176345 0.89 IGF1R (0.53) IGF1R
SCHEMBL6175543 0.88 IGF1R (0.56) IGF1R
SCHEMBL6173508 0.86 IGF1R (0.56) IGF1R
SCHEMBL6175664 0.86 IGF1R (0.47) IGF1R
SCHEMBL6171531 0.86 IGF1R (0.44) IGF1R
SCHEMBL6172534 0.86 IGF1R (0.40) IGF1RPDE2A
SCHEMBL17558385 0.86 IGF1R (0.56) IGF1R
SCHEMBL6174011 0.85 IGF1R (0.56) IGF1R
SCHEMBL6177118 0.85 IGF1R (0.49) IGF1RPDE2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3188729-A1 CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS Genzyme Corporation (US) 2017-07-12 — — EP disclosed
WO-2016036796-A1 CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS GENZYME CORPORATION (US) 2016-03-10 — — WO disclosed