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SCHEMBL6173885

SCHEMBL6173885

CC(c1ccnc(NS(=O)(=O)c2ccccc2)c1)C1(C(C)c2ccnc(NS(=O)(=O)c3ccccc3)c2)NC(=O)N(c2ccc(SC(F)(F)F)cc2)C1=O

nearest known ligand 0.44

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ IGF1R P08069 14/20 0.44
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ OXTR P30559 1/20 0.38
▸ KMT2A Q03164 2/20 0.35
▸ TSHR P16473 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17558349 0.89 IGF1R (0.56) IGF1R
SCHEMBL6175664 0.87 IGF1R (0.47) IGF1R
SCHEMBL6174011 0.86 IGF1R (0.56) IGF1RKMT2ATSHR
SCHEMBL6176345 0.85 IGF1R (0.53) IGF1R
SCHEMBL6173711 0.85 IGF1R (0.59) IGF1R
SCHEMBL6175947 0.85 IGF1R (0.46) IGF1RKMT2ATSHR
SCHEMBL6175543 0.84 IGF1R (0.56) IGF1R
SCHEMBL6173078 0.83 IGF1R (0.45) IGF1RSMN1; SMN2
SCHEMBL6173508 0.83 IGF1R (0.56) IGF1R
SCHEMBL17558385 0.82 IGF1R (0.56) IGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1599464-A2 NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS Aventis Pharma S.A. (FR) 2005-11-30 — — EP disclosed
WO-2004070050-A2 CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS AVENTIS PHARMA S.A. (FR) 2004-08-19 — — WO disclosed