SCHEMBL6175789

SCHEMBL6175789

CC(C)(C)OC(=O)NC1CN(C2CCCCC2)c2ccccc2NC1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.43
GAA P10253 2/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
OPRM1 P35372 3/20 0.43
OPRD1 P41143 3/20 0.43
OGFRL1 Q5TC84 3/20 0.43
OPRK1 P41145 2/20 0.43
KMT2A Q03164 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
PIM1 P11309 1/20 0.41
PIM3 Q86V86 1/20 0.41
PIM2 Q9P1W9 1/20 0.41
CALCRL Q16602 4/20 0.39
IDO1 P14902 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
HDAC6 Q9UBN7 1/20 0.38
MAPK10 P53779 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6176794 1.00 EPHX2 (0.43) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6176058 1.00 EPHX2 (0.43) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6175781 1.00 EPHX2 (0.43) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6176897 0.99 EPHX2 (0.44) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6176893 0.99 EPHX2 (0.44) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6176933 0.89 EPHX2 (0.44) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6175862 0.87 HSD17B10 (0.40) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL7950958 0.87 HSD17B10 (0.40) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6178496 0.86 EPHX2 (0.39) EPHX2GAAKDM4EALDH1A1MAPT
SCHEMBL6178497 0.86 EPHX2 (0.39) EPHX2GAAKDM4EALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12485179-B2 Cholecystokinin B receptor targeting for imaging and therapy PURDUE RESEARCH FOUNDATION (US) 2025-12-02 US disclosed
US-20220273803-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY PURDUE RESEARCH FOUNDATION 2022-09-01 US disclosed
US-11344623-B2 Cholecystokinin B receptor targeting for imaging and therapy PURDUE RESEARCH FOUNDATION (US) 2022-05-31 US disclosed
US-20200384114-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY PURDUE RESEARCH FOUNDATION 2020-12-10 US disclosed
US-10765756-B2 Cholecystokinin B receptor targeting for imaging and therapy PURDUE RESEARCH FOUNDATION (US) 2020-09-08 US disclosed
US-20190076538-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY PURDUE RESEARCH FOUNDATION 2019-03-14 US disclosed
US-10080805-B2 Cholecystokinin B receptor targeting for imaging and therapy PURDUE RESEARCH FOUNDATION (US) 2018-09-25 US disclosed
US-20150050212-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY PURDUE RESEARCH FOUNDATION 2015-02-19 US disclosed
WO-2013126797-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY PURDUE RESEARCH FOUNDATION (US) 2013-08-29 WO disclosed
EP-0945445-B9 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2005-12-28 EP disclosed
EP-1234818-B1 CALCIUM SALTS OF 1,5-BENZODIAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SALTS AND DRUGS CONTAINING THE SAME ZERIA PHARM CO LTD (JP) 2004-09-08 EP disclosed
US-6747022-B2 TREATING DIGESTIVE TRACT DISEASE RESULTING FROM EXCESSIVE SECRETION OF GASTRIC ACID ZERIA PHARMACEUTICAL CO., LTD. (JP) 2004-06-08 US disclosed
EP-0945445-B1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARM CO LTD (JP) 2003-09-03 EP disclosed
US-20030096809-A1 Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same ZERIA PHARMACEUTICAL CO., LTD. (JP) 2003-05-22 US disclosed
EP-1234818-A1 CALCIUM SALTS OF 1,5-BENZODIAZEPINE DERIVATIVES, PROCESS FOR PRODUCING THE SALTS AND DRUGS CONTAINING THE SAME Zeria Pharmaceutical Co., Ltd. (JP) 2002-08-28 EP disclosed
US-6344452-B1 GASTRIN RECEPTOR ANTAGONIST, GASTROINTESTINAL DISORDERS, ETC ZERIA PHARMACEUTICALS CO., LTD. (JP) 2002-02-05 US disclosed
US-6239131-B1 WHICH HAVE GASTRIN AND/OR CCK-B (CHOLECYSTOKININ-B) RECEPTOR ANTAGONISM, USEFUL AS REMEDIES FOR GASTRIC ULCER AND GASTROINTESTINAL MOVEMENT DISORDER. ZERIA PHARMACEUTICAL CO., LTD. (JP) 2001-05-29 US disclosed
EP-1085014-A1 1,5-BENZODIAZEPINE DERIVATIVES Zeria Pharmaceutical Co., Ltd. (JP) 2001-03-21 EP disclosed
EP-0945445-A1 1,5-BENZODIAZEPINE DERIVATIVES ZERIA PHARMACEUTICAL CO., LTD. (JP) 1999-09-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11344623-B2 Cholecystokinin B receptor targeting for imaging and therapy CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885
US-10765756-B2 Cholecystokinin B receptor targeting for imaging and therapy CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885
US-20190076538-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885
US-20200384114-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885
US-10080805-B2 Cholecystokinin B receptor targeting for imaging and therapy CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885
US-20030096809-A1 Calcium salts of 1,5-benzodiazepine derivatives, process for producing the salts and drugs containing the same CCKBR, CCKAR, GABRB1 EPHX2 2897/4885GAA 1647/4885KDM4E 2578/4885
US-12485179-B2 Cholecystokinin B receptor targeting for imaging and therapy CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885
US-20150050212-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885
US-20220273803-A1 CHOLECYSTOKININ B RECEPTOR TARGETING FOR IMAGING AND THERAPY CCKBR, CCKAR, GRPR EPHX2 2332/4885GAA 2876/4885KDM4E 4778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.