Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 2/20 | 0.39 |
| ▸ | CBLB | Q13191 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172184 | 0.94 | NPC1 (0.39) | NPC1RAB9ACBLBALDH1A1IGF1R | |
| SCHEMBL6176337 | 0.92 | NPC1 (0.39) | NPC1RAB9ACBLBALDH1A1MAPK14 | |
| SCHEMBL6175133 | 0.88 | GRM5 (0.43) | NPC1RAB9ACBLBALDH1A1MAPK14 | |
| SCHEMBL6176013 | 0.86 | IGF1R (0.41) | NPC1RAB9AHTR1FMAPK14IGF1R | |
| SCHEMBL6174034 | 0.85 | CBLB (0.36) | NPC1RAB9ACBLBALDH1A1IGF1R | |
| SCHEMBL6174217 | 0.85 | IGF1R (0.38) | NPC1RAB9ACBLBALDH1A1IGF1R | |
| SCHEMBL6175377 | 0.84 | IGF1R (0.35) | CBLBALDH1A1MAPK14IGF1R | |
| SCHEMBL6173894 | 0.83 | IGF1R (0.37) | IGF1R | |
| SCHEMBL6173893 | 0.83 | LMNA (0.39) | CBLBALDH1A1NR3C2IGF1R | |
| SCHEMBL6177752 | 0.82 | IGF1R (0.37) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |